Mr Akeredolu died at about 2 a.m. on Wednesday at a German hospital where he was receiving treatment, a senior government official in Ondo State told Premium Times.
He died of leukemia and prostate cancer, two ailments that had made him incapacitated for several months.
The governor, aged 67, died on Wednesday morning in Lagos after a prolonged health battle.
Akeredolu, a Senior Advocate of Nigeria (SAN), and former president of the Nigerian Bar Association (NBA), was a second-term governor before his death.
The governor had to be flown abroad for treatment for a medical condition in June. He had returned to Nigeria in September after months overseas but stayed in Ibadan, the Oyo State capital.
As his health worsened, Akeredolu was under intense pressure from opposition parties and activists to resign or hand over power to his deputy, Lucky Aiyedatiwa, in line with the 1999 constitution.
Also, the governor’s loyalists in the state House of Assembly were at loggerheads with Aiyedatiwa attracting President Bola Tinubu’s intervention.